Revista Egitania Sciencia - Volume 16 | ARTICLE

Title: COMPARATIVE STUDY OF NATURAL AND SEMISYNTHETIC PENICILLINS ANTIBIOTICS IN ENTEROCOCCUS FAECALIS AND E. FAECIUM

Author: Helena Pimentel

Publication: Revista Egitania Sciencia - Volume 16

Abstract:
This study aimed to compare the antibacterial effect of a natural antibiotic and other semisynthetics, in order to assess whether the source may have some influence on bacterial resistance and sensitivity mechanisms. Since they have different physical, chemical and pharmacological properties, the antibacterial spectrum and action mechanism are also divergent.The antibacterial effect was analyzed in Gram positive bacteria Enterococcus faecalis and Enterococcus faecium, according to gender, in 314 users (162 males: 68,49±21,59 years and 152 females: 61,15±23,04) of a Hospital Unit. Bacteria were isolated from the urine; pus; biological liquid; blood cultures; sputum and catheter. To assess the antibacterial effect we determined the Antibiotics Minimum Inhibitory Concentration under study, which showed that most of the isolates were of the Enterecoccus faecalis specie (82%) vs the faecium species (18%). We observed a significant effect of the bacterium in differences between sensitivity and resistance between the two species. With respect to resistance, both antibiotics were more resistant to the species faecium (penicillin G: 91,2%, ampicillin: 89,5%) compared to faecalis (penicillin G: 33,5%, ampicillin: 33,5 %). Regarding sensitivity, the reverse happened: Both antibiotics were more sensitive to faecalis (penicillin G, 66,5%; ampicillin: 66,5%) compared to the faecium species (penicillin G: 91,2%, ampicillin: 89,5%). We observed statistically significant differences in the antibacterial effect of penicillin G and ampicillin following the two species studied. We found the same trend in relation to gender.

Keywords: antibacterial effect; Enterococcus; inhibitory minimum concentration, penicillin G, ampicillin




               INSTITUTO POLITÉCNICO DA GUARDA | Av. Dr. Francisco Sá Carneiro, 50 | 6300 - 559 Guarda | Tel.+351271220100 | Fax +351271222690